Publications

Peer-reviewed research from the Bazelet science team

Opioid-sparing effect of a cannabinoid formulation in treating acute radicular pain: a randomized controlled trial

Journal of Cannabis Research, 2026

Formulation developed and supplied by Bazelet. Three of the authors are Bazelet researchers.

A randomized, double-blind, placebo-controlled trial at Hadassah Medical Center. A single sublingual dose of a THC, CBD and terpene formulation roughly halved morphine consumption over 24 hours in patients hospitalized with severe acute radicular pain, without increasing pain intensity or causing serious adverse effects.

DOI · 10.1186/s42238-026-00494-w

Synergistic and additive terpene–THC interactions in cannabinoid CB1 and CB2 receptors

Biochemical Pharmacology, 2026

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

Shows that selected cannabis terpenes amplify THC’s activation of both the CB1 and CB2 receptors, several of them synergistically — a mechanistic basis for designing terpene-enriched formulations.

PubMed · 42349621

Selective activation of cannabinoid receptors by cannabis terpenes

Biochemical Pharmacology, 2025

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

Shows that individual cannabis terpenes can activate the CB1 and CB2 receptors on their own, and that different terpenes behave differently.

PubMed · 41173057

Inconsistency in the composition of the smoke of a cannabis cigarette as smoking progresses

Cannabis and Cannabinoid Research, 2024

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

Measures how the composition of cannabis smoke changes from the first puff to the last, with implications for consistent dosing.

PubMed · 37847234

Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation

Biochemical Pharmacology, 2023

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

Finds that specific terpenes increase THC's activity at the CB1 receptor.

PubMed · 37084981

Vapor pressure, vaping, and corrections to misconceptions about medical cannabis' active ingredients

Cannabis and Cannabinoid Research, 2023

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

Clarifies how processing, evaporation and vaping change a product's actual composition and dose.

PubMed · 35442765

Optimal treatment with cannabis extract formulations via terpene content and enrichment with selected monoterpenes

Molecules, 2022

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

Compares terpene content in cannabis flower and in extracts made from it, showing a significant loss of the more volatile terpenes during extraction.

PubMed · 36296511

Terpene-enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: case report

Frontiers in Pharmacology, 2022

Study initiated by Bazelet. Co-authored by Bazelet R&D researchers.

A clinical case report on enriching a CBD oil with selected terpenes.

PubMed · 36386202

Concerns about recommendations for perioperative cannabis use

JAMA Surgery, 2021

Commentary co-authored by Bazelet researchers.

A peer-reviewed correspondence on cannabis use around the time of surgery.

PubMed · 34132761

Anesthetic considerations in medical cannabis patients

Current Opinion in Anaesthesiology, 2020

Review co-authored by Bazelet researchers.

A review of anesthetic considerations for patients using medical cannabis.

PubMed · 33093301

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