A randomized, double-blind, placebo-controlled trial at Hadassah Medical Center. A single sublingual dose of a THC, CBD and terpene formulation roughly halved morphine consumption over 24 hours in patients hospitalized with severe acute radicular pain, without increasing pain intensity or causing serious adverse effects.
DOI · 10.1186/s42238-026-00494-wShows that selected cannabis terpenes amplify THC’s activation of both the CB1 and CB2 receptors, several of them synergistically — a mechanistic basis for designing terpene-enriched formulations.
PubMed · 42349621Shows that individual cannabis terpenes can activate the CB1 and CB2 receptors on their own, and that different terpenes behave differently.
PubMed · 41173057Measures how the composition of cannabis smoke changes from the first puff to the last, with implications for consistent dosing.
PubMed · 37847234Finds that specific terpenes increase THC's activity at the CB1 receptor.
PubMed · 37084981Clarifies how processing, evaporation and vaping change a product's actual composition and dose.
PubMed · 35442765Compares terpene content in cannabis flower and in extracts made from it, showing a significant loss of the more volatile terpenes during extraction.
PubMed · 36296511A clinical case report on enriching a CBD oil with selected terpenes.
PubMed · 36386202A peer-reviewed correspondence on cannabis use around the time of surgery.
PubMed · 34132761A review of anesthetic considerations for patients using medical cannabis.
PubMed · 33093301For distributors, importers, pharmacies and pharma partners across regulated markets.
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