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Innovation 2021-01-11T11:08:00+00:00

AECAH-506 Cannabis oils PR

Bazelet launches first-of-the kind, proprietary, terpene-enriched medical cannabis oilsspecially designed for medical needs such as women health, pain treatment, improved sleep and special needs of the elderly population
Bazelet, the largest medical company in Israel, has made a breakthrough in medical cannabis products, in launchingmultiple lines of terpene-enriched cannabis oils, each one of which being specifically designed for one of various indications, symptoms and personal needs. Bazelet terpene-enriched products are optimized for woman health, for elderly population needs, for specific types of pains (muscle, joint, neuropathic), and for impr0ved night sleep etc.Bazelet also provides patent-protected terpene blends to be added to extracts produced in North America.
Or-Akive, Israel
Bazelethas invented a unique way of formulating of medical cannabis oils. Bazelet, doesn’t depend on developing new strains in order to form a large variety of better-performing new oils. Instead, Bazelet’s TOP technologygenerates improved new oils by blending extracts and by controlling their terpene content, particularly by enriching withscientific-based terpenes selection.
Cannabis inflorescence contains 10-20 different terpenes, varying in amount and proportion and determining the characteristic aroma of the various strains. Processing modifies the terpenes content and, most importantly the terpene profile. Terpenes content of oils is, in many cases, less than one half that of inflorescence and the proportion of low-boiling point terpenes in oil is much smaller than that in the inflorescence.
But this is not mainly about aroma. Terpenes play an important medical role, individually (as in aromatherapy) and, more importantly, in modulating the activity of the cannabinoids in the cannabis oil. Generating oils of exactly selected terpenes composition is easy and is achieved by simple industrial processes. Undesired terpenes are removed by evaporation, while desired terpenes are added, typically ones sourced from plants other than cannabis, e.g.lavender and citrus. The terpene content of Bazeletoils is 50-100% greater than those of common cannabis oils and are therefore referred to as terpenes-enriched.
While manufacturing many formulations of exact composition is straightforward, the main challenge is to discover the preferred composition for each indication or symptom. Some players in the cannabis industry try to collect as much of the terpenes lost during processing and add them back to the oil in order to regenerate the terpene profile of the inflorescence. This approach is questionable, keeping in mindthe obvious – the terpene profile of each strain is selected by nature to serve the needs of the plant, e.g. protection from plant diseases, rather than to serve human needs.
Bazelet’sscientific arm, has devoted the last four years to finding which terpenes improves the performance of the cannabis oil for each indication or symptom and which ones have a negative effect. Bazelet has found that given terpenes are helpful in particular indications, but impair the effect in others. Analysis of big data from hundreds of thousands of users, careful study of pre-clinical and clinical data and deep dive into mechanisms of action resulted in formulations specifically designed for different indications. Bazelet has filed about a dozen of patent application families to protect its terpenes-enriched formulations.
As a demonstration, Bazelet has a series of oils for night use and another one for day use. Almost everyone in the cannabis area knows of Indica and Sativa strains, believed to be more suitable for night use and for day use, respectively. What is much less known is that the majority of the terpenes responsible for the difference between the Indica nature and the Sativa nature are lost in the oil manufacturing, so that oils produced from Indica plants do not have Indica nature more than those from Sativa plants. Bazelet enriches its oilswith the lost terpenes, but not only with those. Further improvement is gained by enriching with selected terpenes, for example enriching Sativa oils with terpenes that increase focus and alertness, making it more suitable for day function.
Bazelet technology has an additional attractive feature. In addition to the production of terpenes-enriched oils, Bazelet is ready to supply patent-protected terpenesblends to be added to extracts produced in other Geographies. Since the terpenes are extracted from sources other than cannabis, there is no limitation on shipment. Additionally, as the total amount of terpene blend to be added is about 1-2% of the final oil, a small barrel of a given blend is sufficient for the manufacturing of large amounts of terpene-enriched oil.
Contact person: Hila Arza. +972-4-8414393, office@b-group.co.il

Israel Medical Cannabis CANNAAN conference

Bazelet will participate in the coming Israel Medical Cannabis CANNAAN conference, and will present 8 scientific contributions in the fields of:

  • ACCURATE REPRODUCIBLE TAILOR-MADE MEDICAL CANNABIS PRODUCTS – CHALLENGES AND SOLUTIONS (Oran presentation)
  • RE-THINKING MANUFACTURING AND R&D IN MEDICAL CANNABIS FIRM OF THE FUTURE (Poster)
  • TERPENE-BASED ENTOURAGE EFFECT HAS A GREAT POTENTIAL FOR IMPROVING MEDICAL CANNABIS THERAPEUTIC EFFECT (Poster)
  • CHALLENGES AND NEW DEVELOPMENTS IN CANNABIS EXTRACTION (Poster)
  • CANNABIS VETERINARY PRODUCT; IMPROVING HONEYBEES’ WELL BEING AND HONEY PRODUCTION (Poster)
  • MEDICAL CANNABIS FOR TREATING NEUROLOGICAL CONDITIONS (Poster)
  • THE CANNABIS TOOLBOX – THERAPEUTIC METHODOLOGIES AND CLINICAL GUIDANCE FOR MEDICAL PERSONNEL; ON THE WAY TO EBM (Poster)
  • TRAINING NEW CANNABIS PATIENTS AS A KEY TO SUCCESS AND CONTINUITY OF TREATMENT (Poster)

Cannabis and Neurology

Bazelet’s scientific paper dealing with medical cannabis treatment in various neurological conditions was published in the Neurology journal, the official journal of the Israel Neurological association (link to article in Hebrew)

Download in Hebrew

Bazelet’s new international patent application

Bazelet’s new international patent application (WO2018015886) CANNABIS PRODUCTS AND INDUSTRIAL METHODS FOR PRODUCTION THEREOF is available online.

Abstract: Cannabis products and industrial methods for production thereof. A homogeneous composition comprising cannabinoid-containing comminuted cannabis plant material, where at least 70% weight of the comminuted cannabis plant material is of a size greater than 0.3 millimeter and less than 4.2 millimeters; the composition comprises at least 1% by weight moisture and less than 20% by weight moisture; and the cannabinoid concentration in a 1 gram fraction of at least 10 gram sample of said homogeneous composition, is within 15% of the cannabinoid concentration in a separate 1 gram fraction of said 10 gram sample

Bazelet’s new international patent application

Bazelet’s new international patent application (WO2017182950) CANNABIS-ENRICHED ENZYMATICALLY TREATED THERAPEUTIC COMPOSITION is available online.

 Abstract: A cannabis-enriched enzymatically treated therapeutic composition. A therapeutic composition is described including water, glucose, glucose reaction product other than sucrose and fructose; a selected amount of a cannabinoid, a cannabinoid reaction product; optionally a terpene and optionally a terpene reaction product. Methods of making and using the compositions are also described.